There are several things you can do if you're saddled with high-interest debt such as credit cards or home equity loans, the end goal of which is to just be free of this kind of debt, since these are some of the primary ways that the big financial institutions make their money.
--Look it in the Face: This one sounds strange, but it really does work. Many people are in their current situations because they simply cannot face the mountain of home equity loan debt covering over the mountain of credit card debt, and so on. Your financial life will only change when you face your financial fears head-on and commit to a plan that will probably mean being more realistic about your finances. This might mean (until you're totally out from under the burden of this debt), cutting back on restaurants, no retail therapy, sending your kids to public school, or whatever (for you) is going to make your dollars go farther. From now on, you will need to commit to a) not adding to your high-interest debt, and b) using whatever money you can save in your budget to overpay your high-interest loans.
--Pay Down as Much As Possible: No sugar-coating here: it is difficult to refinance a home equity loan right now, especially if you're underwater with your home equity. Your best bet for this is to take whatever liquid money you have in the bank (after your two-month emergency fund, of course) and throw it at the balance of that home equity loan.
--Write it Off: This is happening less now that the economy has started to turn around, but I do know several people who have gotten their loans restructured or even forgiven based on financial hardship. This is where the bank agrees to lower the interest rate on your loan or even restructures it so you actually owe less. Your payments end up being lower (at least for now) and you stay in your home while you get back on your feet financially. You definitely need an expert for this, though-- don't expect to just call up Bank of America or Chase and ask for the "loan modification department." One good place to start is eHomeConnect.net-- they are a national network of specialists that can either help you with a short sale (if you're wanting to get out of your home) or they can refer you over to someone who can help you with a loan mod.